Serotonin

“Serotonin Syndrome in the Perioperative Period”

SEROTONIN SYNDROME OVERVIEW:

  • A drug induced condition that results from the effects of toxic levels of the neurotransmitter serotonin (5-HT)
  • Rare occurrence and resemblance to other conditions makes it difficult to diagnose
  • Classic triad
    • Mental state changes
      • Agitation, confusion
    • Autonomic hyperactivity
      • Sweating, fever, tachycardia, tachypnea
    • Neuromuscular abnormalities
      • Tremor, clonus, hyperreflexia, rigidity

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